ALL-C-2533

What is AMD?

Age-Related Macular Degeneration (AMD) is an eye condition that results in loss of vision among people over the age of 50. An extremely gradual process, the vision loss is not entirely noticeable until after a long period of time. This is a result of damage or trauma to the macula, a small area near the center of the retina. The macula is necessary for centrally sharp vision, which allows us to see objects straight ahead. Although the degeneration does not lead to complete blindness, objects in the field of vision appear as distorted, blurry, or dark.

Mode of Action

ALL-C-2533 targets vascular endothelial growth factor (VEGF), a signal protein involved in the formulation of blood vessels. Excess vasucularization around the retina lead to a separation of the retinal layers. Inhibition of VEGF can reduce retinal angiogenesis and reverse its adverse effects.

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